Increases FSH Receptors and Estradriol Release
Whether increased granulosa cell sensitivity to FSH arises primarily from the ovary or secondarily as a result of non ovarian factors is unknown. Studies have shown that granulosa cells from PCOS have greater binding of FSH compared with normal ovaries.
1. FSH Receptor Hyper-responsiveness and Hyperstimulation
Despite a lack of ovulation, studies have demonstrated that PCOS granulosa cells are extremely sensitive to follicle-stimulating hormone (FSH) stimulation when compared with normal cells.Studies find women with PCOS have estradiol secretion in response to FSH (during stimulation) that is comparable to normal women. Yet, beyond a certain threshold […]